The development of Bletilla striata polysaccharides preparations

Bletilla striata polysaccharide,also know as Hyacinth bletilla,is a water-soluble polysaccharide extracted from the dried tubers of orchid plant Bletilla striata. Bletilla striata polysaccharide is apolymer composed of multiple monosaccharides(a-mannose, B-mannose andβ-glucose) connected by glycosidic bonds.It is the main active ingredient of Bletilla striata medicinal materials.It has hemostasis,promotes wound healing,and inhibits Antibacterial,anti-ulcer,anti-tumor and other pharmacological activities.At the Same time, Bletilla striata polysaccharide is also a natural non-toxic, non-irritating polymer material with high bio compatibility and bio adhesiveness.It can be used as the main medicine of preparations and as pharmaceutical adjuvant.The feature has great potential for development in the field of pharmaceutical preparations.
Application of Bletilla striata polysaccharide as Main Drug in Pharmaceutical Preparation
Bletilla striata polysaccharide can accelerate wound healing speed, shorten average wound healing time, improve wound healing quality, promote endothelial cell adhesion and adherence to the wall, and has a certain antibacterial effect, so it can be used for the treatment of trauma.Using angelica extract and white and polysaccharides as the main medicine, an emulsification method was used to prepare rosettes and creams for preventing and treating skin chapped.The results show that the rose cream is delicate,has good spread ability,good stability of the finished product, low skinirritation,and stable and controllable quality.The results of clinical trials showed that the clinical effective rate of Rose and Cream in the treatment of chapped hands and feet reached 91.3%.
Coating agent
Using white and polysaccharides,chlorhexidine acetate, borneol,cork,polygonum cuspidatum, the main drugs, sodium carboxymethylcellulose,glycerin as auxiliary materials, the preparation of various burns and scalds, skin infections, skin ulcers compound white and coating Film agent. Animal experiment results show that the coating agent has a good healing effect on rat skin hot water scald, rat skin steam scald and rat skin open flame burn model.
Starting from the pharmacological effects of Bletilla striata polysaccharides to stop bleeding and promote ulcer healing, Bletilla striata polysaccharides are used as the main medicine,ethanol is the solvent, and carboxymethylcellulose sodium is supplemented to
enhance the slow-release effect, and a compound Bletilla striata for oral ulcers is prepared.And lotion, its glue has high adhesiveness, good film formation and moderate
Bletilla striata polysaccharides have the functions of astringent hemostasis, swelling and muscle growth, and tissue protection, and can be used for the development of hemostatic products.By freeze-drying method,Bletilla striata polysaccharide and modified
starch were compounded to prepare Bletilla striata hemostatic powder.Experimental results show that Bletilla striata hemostatic powder has a good hemostatic effect, does not cause guinea pigskin irritation and allergic reactions, can be completely degraded,and has good bio compatibility.
Flexible liposome
The flexible liposome of Bletilla striata polysaccharide prepared by thin film evaporation-ultrasonic dispersion method has an encapsulation rate greater than 85%, drug loading is about 12%, and the drug utilization rate is greater than 55%, which is a good solution for Bletilla striata polysaccharides.The problem of poor transdermal absorption caused by its water solubility.
Oral Adhesive Tablets
Taking advantage of the bio adhesive and pharmacological activities of white and polysaccharides, the oral adhesive tablets of white and polysaccharides prepared by freeze-drying methods how that the oral adhesive tablets made by mixing 4%of white and polysaccharides and 7%glycerin have excellent performance.Physical and chemical properties, the oral adhesive tablet can promote oral mucosal damage and repair in rabbits with oral ulcers.
The application of Bletilla striata polysaccharide as excipients in pharmaceutica preparations
Gel matrix
Using seabuckthorn seed oil as the raw material and Bletilla striata polysaccharide as the gel skeleton material, the seabuckthorn seed oil is dispersed in the Bletilla striata polysaccharide gel liquid in the form of particles by high-pressure homogeneous emulsification technology to make an O/W gel emulsion.The experimental results showed that Bletilla striata polysaccharides promoted the coating and dispersion of seabuckthorn seed oil particles on the skin, inhibited the aggregation of oil droplets, and made it have good coating properties and comfort.In addition, the gel emulsion can prevent the Seabuckthorn seed oil from contacting the external environment, thereby preventingthe seabuckthorn seed oil from oxidative deterioration.
Film-forming material of film agent
Bletilla striata polysaccharide has good physical and mechanical strength and adhesion, and is an excellent film-forming material.It can be used as a film-forming material alone, or it can be compounded with medicinal polymer materials such as chitosan, polyvinyl
alcohol, sodium methylcellulose, sodium alginate, prepare a new type of composite film.Especially by changing and adjusting the ratio and composition of the film-forming materials, the release rate of the drug can be flexibly controlled to achieve the purpose of sustained release and immediate release.The hydro b romic acid ophthalmic film made from the combination of Bletilla striata polysaccharide and polyvinyl alcohol has as low-release effect, which can effectively reduce the number of administrations and prolong the drug effect.The sodium methylcellulose and Bletilla striata gum are prepared into a double-layer film, which has quick-release analgesic and anti-inflammatory effects.
Adhesive materials for bio adhesive preparations
Bletilla striata polysaccharide has strong adhesion to gastric mucosa.The residence time in the stomach of injured model rats is longer than that of normal rats, and its adhesion is positively correlated with the concentration of Bletilla striata polysaccharide.The Bletilla striata polysaccharide powder and amoxicillin were mixed, and the PVP ethanol solution was used as the binder to prepare the amoxicillin white and polysaccharide bio adhesive sustained-release capsules.The research results show that Bletilla striata
polysaccharides have good bio adhesion and functional slow-release properties both in vivo and invitro, and can be used as excipients for bio adhesive preparations and sustained-release preparations.
Carrier material for vascular embolic agents
A research team has developed a liquid embolic agent for intracranial aneurysm embolization using Bletilla striata polysaccharides as the main matrix, which acts on rabbit common carotid artery sidewall aneurysms, proving the feasibility of embolization
agents.Taking advantage of this feature, Bletilla striata polysaccharides are often used as abase for embolic agents.The rat model of hepatocellular carcinoma proved that Bletilla striata polysaccharide embolization agent can block the blood supply arteries and collateral circulation of liver cancer, and can effectively inhibit the growth and recurrence of liver cancer.Bletilla striata polysaccharide was used as the carrier of the chemotherapy drug mitomycin C to prepare Bletilla striata polysaccharide mitomycin C suspension.The pharmacokinetic study after canine renal artery embolization was carried out, and Bletilla striata polysaccharide was found as the drug carrier It has as low-release effect and is a new type of chemotherapeutic embolic agent.
Clathrate material
Bletilla striata polysaccharide is formed by the polymerization of mannose and glucose.It contains a large a-helix structure and has the basic structure of an inclusion compound.The use of white and polysaccharides to incorporate active ingredients with unstable inclusion structures can increase its stability and enable the drug to have a certain slow-release effect.The aqueous solution method was used to prepare a powdered inclusion compound of Bletilla striata polysaccharide paeonol.The experiment showed that: Bletilla striata polysaccharide can form a complete inclusion compound with paeonol.
The development of Bletilla striata polysaccharides has long roads and obstacles Bletilla striata polysaccharides are rich in sources, cheap and easy to obtain, have pharmacological activities such as hemostasis, promote wound healing, antibacterial,
anti-ulcer,anti-tumor,etc.,and show good biodegradability, bio compatibility and structural modification.It has shown great potential and application prospects in the application of drug delivery systems, wound dressings and other biological materials.
It should be noted that the structure of Bletilla striata polysaccharide components is complex,there are no fixed process parameters in the extraction and purification process, the structure has not yet been fully resolved, the quality control method is not yet
complete, and the relationship between structural features and functional efficacy has not yet been established.It is clarified that these have affected the further development and utilization of white and polysaccharide-related preparations.At present, research on the dosage form of Bletilla striata polysaccharides is mostly focused on the preparation process and invitro characterization of preparations.There are few pharmacodynamics, pharmacokinetics and clinical studies of preparations. Therefore,the product development and industry of Bletilla striata polysaccharide-related preparations The transformation process still has along way to go.
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